Lack of respiratory depression in paracetamol-codeine combination overdoses
نویسندگان
چکیده
منابع مشابه
Hazards of codeine plus paracetamol compounds.
Sir, Codeine phosphate is a popular drug of abuse and is commonly taken in preparations combined with either aspirin or paracetamol. Preparations containing larger amounts of codeine (30 mg) are especially popular. Opiate tolerance may result in dependent individuals needing to ingest large amounts of these drugs, thus risking potentially fatal paracetamol or aspirin toxicity. A 37-year-old wom...
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We studied 90 adults undergoing surgical removal of at least both lower third molar teeth as day cases under standardized general anaesthesia. Patients were allocated randomly (with stratification for surgeon) to receive tenoxicam 40 mg, tenoxicam 20 mg or placebo i.v. at induction of anaesthesia and orally (effervescent tablets) with food on each of the subsequent 2 days. Panadeine (paracetamo...
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The objective of this study was to quantify the analgesic efficacy of paracetamol and its combination with codeine or caffeine through a systematic overview and meta-analysis of relevant randomized controlled trials (RCTs). Systematic retrieval of relevant clinical trials was carried out using computerized searches, historical searches and communication with manufacturers. The results of RCTs w...
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A 48-year-old man who had undergone thoracotomy for carcinoma of the middle third of his oesophagus developed severe postoperative respiratory depression following intramuscular ketorolac 30 mg 2 h after 150 micrograms epidural buprenorphine. Summation of analgesia by drugs used in combination can have deleterious respiratory effects.
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ژورنال
عنوان ژورنال: British Journal of Clinical Pharmacology
سال: 2017
ISSN: 0306-5251
DOI: 10.1111/bcp.13224